What is a Hereditary Cancer Panel?

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What is a Hereditary Cancer Panel?

GeneHealth’s Hereditary Cancer Panel is a comprehensive genetic test that identifies inherited mutations in genes associated with an increased cancer risk. Using advanced NGS methods, this test analyzes multiple high-penetrance and moderate-risk genes such as BRCA1, BRCA2, MLH1, MSH2, TP53, and others. It enables early detection, personalized risk management, and informed decisions on surveillance or preventive interventions. It is especially vital when there is a strong family history or multiple cancer types present in the family.

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Testing Indications for Hereditary Cancer

Hereditary Breast & Ovarian Cancer
Prostate Cancer
Paraganglioma
Thyroid Cancer
MEN Syndrome
Lynch Syndrome
Endocrine Cancer
Pancreatic Cancer
Renal Cancer
Von-Hippel Lindau Syndrome
Gynecological Cancer
Li-Fraumeni Syndrome
Juvenile Polyposis
Peutz Jeghers
Retinoblastoma
Hereditary Nonpolyposis Colorectal Cancer

Clinical Benefits of Testing

  • Enables risk estimation for secondary cancers and potential relapse.
  • Supports personal and familial risk assessment for inherited cancer syndromes.
  • Allows for early detection, significantly improving clinical outcomes and survival rates.
  • Facilitates active risk management and disease prevention through tailored surveillance and prophylactic surgeries.
  • Determines eligibility for targeted treatments like PARP inhibitors (PARPi) and platinum-based therapies for personalized treatment planning.

Assay Specifications

Indications: Cancer diagnosed at a young age, the presence of multiple primary cancers in the same person, or a cluster of the same/related cancers across multiple relatives on the same side of the family.
Methodology: Next-Generation Sequencing (NGS) + Multiplex Ligation-dependent Probe Amplification (MLPA).
Sample Type: 3–4 ml blood in EDTA tube.
Coverage & Accuracy: Covers SNVs, InDels and CNVs across complete coding regions. Highly optimized bioinformatics pipelines ensure >99% sensitivity and specificity.

Key Highlights of GeneHealth’s Panel

Broad Variant Detection

Accurately identifies SNVs, InDels, and CNVs (Copy Number Variations) for comprehensive and reliable mutation analysis.

Full Coding Region Coverage

Covers the entire coding regions of target genes, ensuring no crucial data is missed by solely relying on common mutation hotspots.

Non-Coding Variant Inclusion

Goes beyond standard testing by successfully reporting clinically relevant variants found in regulatory and deep intronic genomic regions.

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